From Scientists unveil ultra-thin electronics that can dissolve into the body
the team’s inventions include a biodegradable semi-conductive polymer, disintegrable and flexible electronic circuits, and a biodegradable substrate material for mounting these electrical components onto.
Totally flexible and biocompatible, the ultra-thin film substrate allows the components to be mounted onto both rough and smooth surfaces.
All together, the components can be used to create biocompatible, ultra-thin, lightweight and low-cost electronics for applications as diverse as wearable electronics to large-scale environmental surveys.
Maybe this is one of the many approaches we’ll use for biohacking or as wearable technology in the future.
From The shock tactics set to shake up immunology : Nature
The human vagus nerve contains around 100,000 individual nerve fibres, which branch out to reach various organs. But the amount of electricity needed to trigger neural activity can vary from fibre to fibre by as much as 50-fold.
Yaakov Levine, a former graduate student of Tracey’s, has worked out that the nerve fibres involved in reducing inflammation have a low activation threshold. They can be turned on with as little as 250-millionths of an amp — one-eighth the amount often used to suppress seizures. And although people treated for seizures require up to several hours of stimulation per day, animal experiments have suggested that a single, brief shock could control inflammation for a long time10. Macrophages hit by acetylcholine are unable to produce TNF-α for up to 24 hours, says Levine, who now works in Manhasset at SetPoint Medical, a company established to commercialize vagus-nerve stimulation as a medical treatment.
By 2011, SetPoint was ready to try the technique in humans, thanks to animal studies and Levine’s optimization efforts. That first trial was overseen by Paul-Peter Tak, a rheumatologist at the University of Amsterdam and at the UK-based pharmaceutical company GlaxoSmithKline. Over the course of several years, 18 people with rheumatoid arthritis have been implanted with stimulators, including Katrin.
For the images of the actual device, check Core77. They also have implantable bioelectronic devices.
From Multi-functional Flexible Aqueous Sodium-Ion Batteries with High Safety
The development of wearable and implantable electrical devices has been in great demand recently. However, most existing energy storage systems are based on strong corrosive or toxic electrolytes, posing a huge safety hazard as a result of solution leakage.
Here, we have developed a family of safe and flexible belt- and fiber-shaped aqueous sodium-ion batteries (SIBs) by using various Na+-containing aqueous electrolytes, including Na2SO4 solution, normal saline, and cell-culture medium. The resulting SIBs exhibit high flexibility and excellent electrochemical performance and can be safely applied in wearable electronics. Flexible SIBs with normal saline or cell-culture medium as the electrolyte showed excellent performance, indicating potential application in implantable electronic devices.
In addition, the fiber-shaped electrode in normal saline or cell-culture medium electrolyte can consume O2 and change the pH, implying promising application in biological and medical investigations.
From Go ahead and cry — your tears might power the batteries of the future – The Verge
In a lot of the flexible batteries out there, these electrolyte solutions are made out of strong acids or toxic chemicals, the study says. That stuff is corrosive, flammable, or toxic, and you definitely don’t want it dribbling onto or into your body. That’s why scientists at Fudan University in China came up with a way to replace these toxic electrolyte solutions with something much less harmful.
The researchers experimented with a few different types of electrolyte solutions. The one that worked best was sodium sulfate, which is sometimes used as a laxative. But saline solutions, which are literally diluted salt water, also worked well. Eventually, bodily fluids like blood, sweat, or tears might take over the roll of the electrolyte solution to power medical implants, the study says.
From What Comes After Wearables? Try “Invisibles”
a group of researchers at MIT have developed a remote sleep sensing system that uses radio waves to capture data about your brain waves while you sleep–and AI to read them–without ever touching your body. It consists of a laptop-sized wireless device that emits radio signals. When put in the user’s bedroom, the waves detect even the slightest movement of the body. The system doesn’t just do the job of a sleep-tracking wearable without the wearable; it also just provides data at a similar level of accuracy as a sleep lab.
In order to cut out all the extraneous information her system records, she developed a machine learning algorithm that can extract sleep stages–light, deep, and REM sleep–out of the mess of data. The algorithm was trained on a sleep dataset of 25 individuals for a total of 100 nights of sleep, taken using an FDA-approved device that uses EEG to record brain waves.
The results are 80% accurate
From Viome raises $15 million to analyze your gut and give you health tips | VentureBeat
Viome, a startup that does RNA analysis of all living organisms in the gut, today announced funding of $15 million to create unique molecular profiles for its customers by identifying and quantifying all the microorganisms that live in the gut. These include bacteria, viruses, yeast, mold, and fungus.
Viome uses artificial intelligence to analyze these results and figure out what’s going on in your gut — certain imbalances can cause chronic illnesses, according to Viome’s cofounder and CEO, Naveen Jain.
“There are other companies out there that can analyze your microbiome, but they use 16S testing, which only looks at a portion of bacteria and only at a genus level (any two people have 95 percent similarity in their microbiome at a genus level),” Jain wrote in an email to VentureBeat. “We look at all living organisms at a strain level and also understand what they are doing.”
From We Will End Disability by Becoming Cyborgs – IEEE Spectrum
It’s quite possible that Alzheimer’s patients of the future will be equipped with memory prosthetics derived from the devices being invented in Berger’s lab today. His work began with delicate electrodes inserted into a rat’s hippocampus, the brain structure responsible for encoding memory. Berger first deciphered the relationship between the input signals from neurons that process a brief learning experience—for example, which lever a rat should press to gain a sip of sugar water—and the output signals from neurons that send the information on to be stored as a memory.
Once he had mapped the correlations between the two electrical patterns, Berger could record an input signal and predict the output signal—in other words, the memory. He didn’t need to know which part of the input pattern coded for the dimensions of the lever or for the taste of the sweet reward. He simply mathematically generated the output signal and sent it to the memory-storage neurons. “It’s like translating Russian to Chinese when you don’t know either language,” Berger says. “We don’t want to know either language; we just want to know how this pattern becomes that pattern.”
Berger proved that he could implant the memory of the lever-and-reward test in a rat with a damaged hippocampus that was unable to form memories on its own. Even more remarkable, he implanted the memory in a rat that had never before undergone the test or seen the levers. The rat entered the test chamber for the first time, pressed the correct lever, and sucked down the sweet nectar.
From Bioresorbable silicon electronic sensors for the brain – Nature
Many procedures in modern clinical medicine rely on the use of electronic implants in treating conditions that range from acute coronary events to traumatic injury. However, standard permanent electronic hardware acts as a nidus for infection: bacteria form biofilms along percutaneous wires, or seed haematogenously, with the potential to migrate within the body and to provoke immune-mediated pathological tissue reactions. The associated surgical retrieval procedures, meanwhile, subject patients to the distress associated with re-operation and expose them to additional complications.
Here, we report materials, device architectures, integration strategies, and in vivo demonstrations in rats of implantable, multifunctional silicon sensors for the brain, for which all of the constituent materials naturally resorb via hydrolysis and/or metabolic action, eliminating the need for extraction. Continuous monitoring of intracranial pressure and temperature illustrates functionality essential to the treatment of traumatic brain injury; the measurement performance of our resorbable devices compares favourably with that of non-resorbable clinical standards.
In our experiments, insulated percutaneous wires connect to an externally mounted, miniaturized wireless potentiostat for data transmission. In a separate set-up, we connect a sensor to an implanted (but only partially resorbable) data-communication system, proving the principle that there is no need for any percutaneous wiring. The devices can be adapted to sense fluid flow, motion, pH or thermal characteristics, in formats that are compatible with the body’s abdomen and extremities, as well as the deep brain, suggesting that the sensors might meet many needs in clinical medicine.
From Is Elysium Health’s Basis the Fountain of Youth? — Science of Us
Others who’d taken Basis before me had described effects including fingernail growth, hair growth, skin smoothness, crazy dreams, increased stamina, better sleep, and more energy. Once I began taking it, I did feel an almost jittery uptick in mojo for a few days, and I slept more soundly as well. Then those effects seemed to recede, and there were also mornings where I felt a little out of it. If these were placebo effects, they were weird ones, because they didn’t make me feel better, only different.
Because the two active compounds in Basis, pterostilbene and NR, are natural (occurring in blueberries and milk, respectively) and have long been available separately as supplements, Elysium has been able to skip the FDA gauntlet and sell its capsules immediately.
The agility that comes with bypassing federal regulation has an obvious cost: Guarente and his advisory board are the only scientific credibility Elysium can claim. The company stresses that it is using only compounds supported by hundreds of peer-reviewed papers, that it enforces high manufacturing standards, and that it is conducting a human trial (currently 120 people between the ages of 60 and 80 are participating).
but most importantly
A large number of men who have made fortunes in Silicon Valley believe so — or at least are trying to recast aging as merely another legacy system in need of recoding. Oracle co-founder Larry Ellison’s Ellison Medical Foundation has spent more than $400 million on aging research. In 2013, Alphabet’s Larry Page announced a moonshot life-extension project called Calico, and XPrize founder Peter Diamandis partnered with genome sequencer J. Craig Venter to found a competing company called Human Longevity Inc. Paul F. Glenn, an 85-year-old venture capitalist who watched his grandfather die of cancer, launched an aging-science foundation more than 50 years ago that has since funded a dozen aging-research centers around the country. Peter Thiel is 37 years Glenn’s junior but equally desperate to find a death cure: He has given at least $3 million to the Methuselah Foundation, the research vehicle for the extravagantly bearded, Barnumesque immortality promoter Aubrey de Grey. Thiel has also said he takes a daily dose of human growth hormone, and he was reported to have seriously explored the transfusion of blood from the young to the old.
From Omega Ophthalmics is an eye implant platform with the power of continuous AR | TechCrunch
… lens implants aren’t a new thing. Implanted lenses are commonly used as a solve for cataracts and other degenerative diseases mostly affecting senior citizens; about 3.6 million patients in the U.S. get some sort of procedure for the disease every year.
Cataract surgery involves removal of the cloudy lens and replacing it with a thin artificial type of lens. Co-founder and board-certified ophthalmologist Gary Wortz saw an opportunity here to offer not just a lens but a platform to which other manufacturers could add different interactive sensors, drug delivery devices and the inclusion of AR/VR integration.
Maybe there’s a surprisingly large audience among the over 60 that is willing to try and get a second youth through biohacking. Maybe over 60s will become the first true augmented humans.
Long piece published by The Verge on the biohacking scene and how these early days devices stop working within a handful of years.
From A Wisconsin company will let employees use microchip implants to buy snacks and open doors – The Verge
A Wisconsin company called Three Square Market is going to offer employees implantable chips to open doors, buy snacks, log in to computers, and use office equipment like copy machines. Participating employees will have the chips, which use near field communication (NFC) technology, implanted between their thumb and forefinger.
They’re essentially an extension of the chips you’d find in contactless smart cards or microchipped pets: passive devices that store very small amounts of information.
From Augmentation of Brain Function: Facts, Fiction and Controversy | Frontiers Research Topic
Augmentation of brain function is no longer just a theme of science fiction. Due to advances in neural sciences, it has become a matter of reality that a person may consider at some point in life, for example as a treatment of a neurodegenerative disease. Currently, several approaches offer enhancements for sensory, motor and cognitive brain functions, as well as for mood and emotions. Such enhancements may be achieved pharmacologically, using brain implants for recordings, stimulation and drug delivery, by employing brain-machine interfaces, or even by ablation of certain brain areas.
I plan to review all of them.
From Nootrobox is now HVMN – THINKING
what does it means to be human in a future molded by automation, robots, and artificial intelligences ?
Our core belief is that the human is a system that can be quantified, optimized, and upgraded. Like any system (regardless of its origin as biological, mechanical, or computational), the human has inputs and outputs. HVMN develops inputs into the human system to optimize for key biometrics including cognitive, physical, and metabolic output.
While our rhetoric and our techniques may be modern, the fundamental human drive to improve oneself is not. The same instincts that drove Egyptian pharaohs, Spanish conquistadors, and Chinese emperors to seek enhancement drive modern biohackers.
Andreessen Horowitz is backing this startup. Worth watching.